intermediate filaments การใช้

• Intermediate filaments are a part of the cytoskeleton of all animals.
• Keratins are heteropolymeric structural proteins which form the intermediate filament.
• Alternatively, these proteins can interact with keratin intermediate filaments.
• This protein is known to interact with intermediate filaments, specifically keratins.
• Synemin has properties very similar to the intermediate filament syncoilin.
• Some animals like the fruit fly do not have any cytoplasmic intermediate filaments.
• In those animals that express cytoplasmic intermediate filaments, these are tissue specific.
• Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton.
• A well documented function of Hsp27 is the interaction with actin and intermediate filaments.
• When the filaggrin binds to keratin intermediate filaments, it causes aggregation in macrofibrils.
• The odontoblastic cell body keeps its tapered structure with cytoskeletal fibres, mainly intermediate filaments.
• In general, phosphorylation destabilizes intermediate filaments.
• Upon differentiation, nestin becomes downregulated and is replaced by tissue-specific intermediate filament proteins.
• Keratin 5, like other members of the keratin family, is an intermediate filament protein.
• The type III intermediate filament Vimentin is phosphorylated by Akt1 at Ser39, preventing its degradation.
• These two categories also represent the first two categories of the superfamily of intermediate filament proteins.
• Integrin alpha6beta4 is an exception : it links to the keratin intermediate filament system in epithelial cells.
• Biologically, calluses are formed by the accumulation of hydrophobic keratin intermediate filaments containing many disulfide bonds.
• Desmin is a subunit of intermediate filaments in cardiac muscle, skeletal muscle and smooth muscle tissue.
• Vimentin is a type III intermediate filament ( IF ) protein that is expressed in mesenchymal cells.